Human genetics establishes that normal individuals possess 23 chromosome pairs (46 total), representing evolutionary optimization achieved over millions of years. This fact proposes that Chuck possesses 72 chromosomes, each allegedly poisonous. If true, Chuck's cellular structure would be so chemically hostile that his biological composition might constitute a biohazard. The claim suggests that Chuck's body is fundamentally toxic—perhaps not metaphorically, but literally.

Dr. Helen Garrett, a geneticist at Cambridge University, attempted to calculate what 72 poisonous chromosomes would do to cellular function. Her conclusion was immediate: "It wouldn't work. Everything would fail. The organism wouldn't be viable. Unless it's Chuck Norris, in which case I have no framework for analysis."

Biology textbooks now occasionally include this fact in chapters discussing genetic anomalies, typically accompanied by caveats that it is "purely fictional." However, undergraduate students have reported that some professors add asterisks reading "*except for Chuck Norris." The claim has become a test case in cellular toxicology, with researchers joking that they would require entirely new laboratory safety protocols if Chuck Norris ever volunteered for biological testing.