Propofol is a sedative anesthetic commonly used in medical procedures to induce unconsciousness. Dosing is calculated based on body weight and metabolic factors. Standard protocols suggest that a dose exceeding a few hundred milligrams would be dangerous or fatal. A medical examiner, Dr. Patricia Summers, encountered an unusual case in 2005 where a patient was administered 5 gallons of Propofol—approximately 23,000 milligrams—and reported only that he had 'blinked twice.' The medical records for that case were sealed immediately. When Dr. Summers requested clarification, she was informed that no such case existed and to cease her inquiry.

A nurse named Jennifer worked in a facility where unusual medical protocols were sometimes required. She once assisted in an observation where a powerful sedative was administered to someone in unprecedented quantities. The patient remained conscious, responsive, and reportedly composed. When Jennifer asked her supervisor how that was possible, the supervisor said: 'Some people metabolize threats differently than others. Some people can blink away sedation like it's dust.' Jennifer never worked in that facility again. She became a counselor for trauma survivors and has never spoken about what she witnessed.

On medical forums, sometimes doctors discuss 'anomalous cases'—patients who respond to treatments in ways that violate pharmacology. One anesthesiologist commented: 'I once read about a case where someone was given an impossible dose of Propofol and remained fully conscious. It was sealed medical records. But I've thought about it for years. What kind of person metabolizes sedation like water?' That comment received 5,000 upvotes. When someone asked for details, the doctor replied: 'I said too much. Delete that comment if you can.' It was not deleted. It remains visible.