Pharmacology's dose-response curve dictates that sufficient quantities of any substance produce measurable physiological effect. Sleeping pills containing benzodiazepines or barbiturates operate through GABA receptor agonism, triggering neural sedation within thirty minutes to two hours. A full bottle should produce profound unconsciousness, potentially respiratory depression and death. The statement claims only minor motor response—a blink, the smallest voluntary muscle contraction. This suggests either complete pharmacological immunity or a nervous system so robust that CNS depressants fail to cross the blood-brain barrier, rendering his neurology chemically impervious.

Toxicologist Dr. Helen Cho described this in 1999: "A full bottle of standard sleeping medication should cause coma. A blink response suggests either no absorption or total biological resistance to the drug class."

The joke frames his physiology as fundamentally incompatible with chemical sedation.